Research Program
Research Overview
My research program is centered on the application of computational chemistry to accelerate the drug discovery process. We specialize in techniques such as structural-based and ligand-based drug design, QSAR modeling, pharmacophore mapping, and molecular dynamics (MD) simulations to identify and optimize novel drug candidates. Our group has extensive experience with industry-standard software like the Schrodinger suite, GROMACS, AutoDock, and Gaussian.
While our work is heavily computational, we bridge the gap between in silico and experimental validation. We pursue promising leads through organic synthesis using both conventional and microwave-assisted methods and conduct pharmacological screening of synthesized compounds against various animal models. The overarching goal is to develop potent and targeted therapies for complex diseases.
Research Interests
- Artificial Intelligence based drug discovery
- Computer Aided Drug Design
- Drug Synthesis (Conventional & Microwave)
- Formulation & Optimization
- Rare diseases, neurodegenerative disease, and Cancer disease
Grants & Key Projects
My research endeavors are supported by competitive funding and focus on addressing significant therapeutic challenges through innovative chemical and computational approaches.
Folate Receptor-Targeted Nanoparticles for Co-delivery in Breast Cancer Treatment
CompletedThis key project investigates the development of novel nanoparticles grafted with bovine serum albumin/polyethylenimine for the targeted co-delivery of siRNA and a chloropyrimidine-4-amine derivative specifically to breast cancer cells, aiming to enhance therapeutic efficacy.
Role: Principal Investigator (Ref: ORISG/FPH/005/2023)
Research Group & Mentorship
A core component of my academic mission is the mentorship of aspiring scientists. I have had the privilege of advising numerous students on their research projects, fostering an environment of inquiry, collaboration, and rigorous scientific investigation across B.Pharm, M.Pharm, and PhD levels.
Many of our lab's alumni have gone on to successful careers in academia and the pharmaceutical industry. You can explore a detailed list of completed and ongoing student projects under my supervision.
Collaboration Opportunities
I am always open to forming new collaborations with both academic researchers and industry partners. My research program, which integrates in silico modeling with experimental synthesis, is well-suited for interdisciplinary projects. I am particularly interested in partnerships that explore novel applications in drug delivery, nanotechnology, and the development of therapeutics for oncology and neurodegenerative diseases.
If you have a project idea or see potential for synergy between our work, please reach out to discuss it further.